HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-Methyloxazolidin-2-one → (R)-3-{6-[4-(4-chlorobenzoyl)piperidine-1-carbonyl]pyridin-3-yl}-4-methyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-Methyloxazolidin-2-one | HCID 2734858 | — |
| Reactant | (5-Bromopyridin-2-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone | HCID 58484577 | — |
| Product | (R)-3-{6-[4-(4-chlorobenzoyl)piperidine-1-carbonyl]pyridin-3-yl}-4-methyloxazolidin-2-one | HCID 54755119 | 83.4% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 31 and using (5-bromopyridin-2-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (2.4 g) described in Preparation Example 35 and (R)-4-methyloxazolidin-2-one (728 mg) described in Preparation Example 25, the title compound (2.1 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-5dc47467ef784151ab188b492d73ec0b |
| Source note | uspto-grants-2013_01 |