4-Bromo-3-methylbenzoic acid → HCID 58484593, compound

HRID 1804015Notes

Reaction equation

HRID 1804015 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[CH3:11].[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:4][C:3]=1[CH3:11]

Participants

3

Reactant 2

HCID 821314-Bromo-3-methylbenzoic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 58484593HCID 58484593, compoundYield 90.7%

Procedure

By reaction and treatment in the same manner as in Preparation Example 67 and using 4-bromo-3-methylbenzoic acid (4.3 g) and 1-(3,5-dimethylpyridin-2-yl)piperazine (3.8 g) described in Preparation Example 47, the title compound (7 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 67
  3. customdescribed in Preparation Example 47

Sources & evidence

ORD record
ord-a2805b3df67944bda68b3231d774eb14
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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