5-Chloro-4-iodo-2-methoxybenzoic acid → HCID 58484862, compound

HRID 1804018Notes

Reaction equation

HRID 1804018 reaction equation
[Cl:1][C:2]1[C:3]([I:13])=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH3:14][C:15]1[C:16]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:17][CH:18]=[C:19]([CH3:21])[CH:20]=1>>[Cl:1][C:2]1[C:3]([I:13])=[CH:4][C:5]([O:11][CH3:12])=[C:6]([C:7]([N:25]2[CH2:26][CH2:27][N:22]([C:16]3[C:15]([CH3:14])=[CH:20][C:19]([CH3:21])=[CH:18][N:17]=3)[CH2:23][CH2:24]2)=[O:9])[CH:10]=1

Participants

3

Reactant 2

HCID 167918585-Chloro-4-iodo-2-methoxybenzoic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Product 1

HCID 58484862HCID 58484862, compoundYield 96.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 67 and using 5-chloro-4-iodo-2-methoxybenzoic acid (1 g) and 1-(3,5-dimethylpyridin-2-yl)piperazine (612 mg) described in Preparation Example 47, the title compound (1.5 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 67
  3. customdescribed in Preparation Example 47

Sources & evidence

ORD record
ord-5a4d16c5623647e0b7599774d96b9a1c
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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