HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-chloro-5-fluorobenzoyl chloride → (4-Bromo-2-chloro-5-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-chloro-5-fluorobenzoyl chloride | HCID 2736226 | — |
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine hydrochloride | HCID 67381379 | — |
| Product | (4-Bromo-2-chloro-5-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484674 | 95.6% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-chloro-5-fluorobenzoyl chloride (1 g) and 1-(3,5-dimethylpyridin-2-yl)piperazine hydrochloride (843 mg) described in Preparation Example 64, the title compound (1.5 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-fcb0767dcc1b44daa77dd02520a36f22 |
| Source note | uspto-grants-2013_01 |