4-Bromo-2-methanesulfonylbenzoic acid → HCID 58484757, compound

HRID 1804021Notes

Reaction equation

HRID 1804021 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1.[Cl:15][C:16]1[C:17]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:18][CH:19]=[C:20]([Cl:22])[CH:21]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:26]2[CH2:27][CH2:28][N:23]([C:17]3[C:16]([Cl:15])=[CH:21][C:20]([Cl:22])=[CH:19][N:18]=3)[CH2:24][CH2:25]2)=[O:8])=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1

Participants

3

Reactant 2

HCID 27610574-Bromo-2-methanesulfonylbenzoic acidHCID 27714311-(3,5-Dichloropyridin-2-yl)piperazine

Product 1

HCID 58484757HCID 58484757, compoundYield 101.4%

Procedure

By reaction and treatment in the same manner as in Preparation Example 1 and using 4-bromo-2-methanesulfonylbenzoic acid (279 mg) and 1-(3,5-dichloropyridin-2-yl)piperazine (232 mg), the title compound (0.5 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 1

Sources & evidence

ORD record
ord-24272f9d214640c683b9531512f50741
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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