HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylboronic acid → 1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | 1-Tert-butyloxycarbonyl-4-(3-chloro-5-(trifluoromethyl)pyridin-2-YL)piperazine | HCID 57366416 | — |
| Product | 1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride | HCID 67380779 | 94.4% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 49 and using 4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (7.3 g), which is the intermediate described in Preparation Example 51, and cyclopropylboronic acid (4.2 g), the title compound (5.8 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-2fe81650481245789a299cf27e8a016c |
| Source note | uspto-grants-2013_01 |