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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804031Generated: November 1, 2026

4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1804031

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-methanesulfonylbenzoic acidHCID 2761057—
Reactant1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochlorideHCID 67380775—
Product(4-Bromo-2-methanesulfonylphenyl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 5848479994.1%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 27 and using 4-bromo-2-methanesulfonylbenzoic acid (558 mg) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride (508 mg) described in Preparation Example 48, the title compound (0.9 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-048171be6f0f45d19e3da7339ee6c77c
Source noteuspto-grants-2013_01