4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Participants

Role	Name	HCID	Charge
Reactant	4-Bromo-2-fluorobenzoyl chloride	HCID 2734026	—
Reactant	1-(3,5,6-Trimethylpyridin-2-yl)piperazine hydrochloride	HCID 67381052	—
Product	(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484847	59.5%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (5 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride (5 g) described in Preparation Example 52, the title compound (5 g) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-5f3c09eaaccb44269bea0e2824d76325
Source note	uspto-grants-2013_01