4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804050Notes

Reaction equation

HRID 1804050 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1.Cl.[CH2:16]([C:18]1[CH:19]=[C:20]([CH3:30])[C:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[N:22][CH:23]=1)[CH3:17]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:27]2[CH2:28][CH2:29][N:24]([C:21]3[C:20]([CH3:30])=[CH:19][C:18]([CH2:16][CH3:17])=[CH:23][N:22]=3)[CH2:25][CH2:26]2)=[O:8])=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1

Participants

3

Reactant 2

HCID 27610574-Bromo-2-methanesulfonylbenzoic acidHCID 673809241-(5-Ethyl-3-methylpyridin-2-yl)piperazine hydrochloride

Product 1

HCID 58484608(4-Bromo-2-methanesulfonylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 99.4%

Procedure

By reaction and treatment in the same manner as in Preparation Example 1 and using 4-bromo-2-(methanesulfonyl)benzoic acid (2.8 g) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine hydrochloride (2.4 g) described in Preparation Example 99, the title compound (4.6 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 1
  3. customdescribed in Preparation Example 99

Sources & evidence

ORD record
ord-7f113b9512044e6783259216dba1e8af
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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