4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(3-ethyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804054Notes

Reaction equation

HRID 1804054 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH2:13]([C:15]1[C:16]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:17][CH:18]=[C:19]([CH3:21])[CH:20]=1)[CH3:14]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:16]3[C:15]([CH2:13][CH3:14])=[CH:20][C:19]([CH3:21])=[CH:18][N:17]=3)[CH2:23][CH2:24]2)=[O:7])=[C:4]([F:11])[CH:3]=1

Participants

3

Reactant 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 673808571-(3-Ethyl-5-methylpyridin-2-yl)piperazine hydrochloride

Product 1

HCID 58484506(4-Bromo-2-fluorophenyl)[4-(3-ethyl-5-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 65.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (1.1 g) and 1-(3-ethyl-5-methylpyridin-2-yl)piperazine hydrochloride (1 g) described in Preparation Example 54, the title compound (1.1 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 8
  3. customdescribed in Preparation Example 54

Sources & evidence

ORD record
ord-78618ebf4b1b4aa59c4cadcde3e694d9
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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