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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804056Generated: October 26, 2026

6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1804056

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromonicotinic acidHCID 238932—
Reactant1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochlorideHCID 67381091—
Product(6-Bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 5848485886%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (2 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (2.5 g) described in Preparation Example 49, the title compound (3.4 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-ebcb6eef44cb4dbf8dac6e066fa75047
Source noteuspto-grants-2013_01