HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzoyl chloride | HCID 2734026 | — |
| Reactant | 1-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride | HCID 67380775 | — |
| Product | (4-Bromo-2-fluorophenyl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484686 | 54.6% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (2.6 g) and 1-(3-cyclopropyl-5-methylpyridin-2-yl)piperazine hydrochloride (2.8 g) described in Preparation Example 48, the title compound (2.5 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-395616b067e5428ea2f398f8f8b4746e |
| Source note | uspto-grants-2013_01 |