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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804060Generated: October 25, 2026

6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

https://huagongshe.com/reaction/1804060

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromonicotinic acidHCID 238932—
Reactant1-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochlorideHCID 67381094—
Product(6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanoneHCID 5848477796.9%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 1 and using 6-bromonicotinic acid (2 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (3.2 g) described in Preparation Example 50, the title compound (4.1 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-9c7c153cd53149cf80c404449b2ee3c6
Source noteuspto-grants-2013_01