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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804074Generated: October 31, 2026

1-Methylimidazolidin-2-one → 1-{5-Chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-one

https://huagongshe.com/reaction/1804074

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methylimidazolidin-2-oneHCID 567600—
Reactant(2-Bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484730—
Product1-{5-Chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidin-2-oneHCID 5848480218.3%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 12 and using (2-bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (960 mg) described in Preparation Example 119 and 1-methyl-2-imidazolidinone (235 mg), the title compound (184 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-46596986df354b69b16f0b451ac1b371
Source noteuspto-grants-2013_01