1-(2,4-Xylyl)piperazine → HCID 58484738, compound

HRID 1804081Notes

Reaction equation

HRID 1804081 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:21][CH2:22][N:23]([C:6]([C:5]2[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=2[CH3:11])=[O:8])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

Product 1

HCID 58484738HCID 58484738, compoundYield 83.3%

Procedure

By reaction and treatment in the same manner as in Preparation Example 60 and using 6-fluoro-4-methylnicotinic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (607 mg), the title compound (870 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 60

Sources & evidence

ORD record
ord-2eee18bd79a24ca5a2efb00d3c18c5d3
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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