Potassium Phosphate, Tribasic → HCID 58484562, compound

Participants

Reaction Steps

To a solution of [4-(5-bromo-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (2.2 g) described in Preparation Example 113 in tetrahydrofuran (15 mL) were added 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (229 mg), palladium acetate (125 mg), tripotassium phosphate (3.12 g) and cyclopropylboronic acid (721 mg), and the mixture was refluxed for 7 hr. After cooling, the mixture was extracted with ethyl acetate, washed with saturated brine, and the solvent was evaporated. The residue was purified by column chromatography to give the title compound (2.39 g).

Provenance & Evidence