6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 58484588, compound

HRID 1804091Notes

Reaction equation

HRID 1804091 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:25][CH2:26][N:27]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:28][CH2:29]2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 67381204HCID 67381204, compound

Product 1

HCID 58484588HCID 58484588, compoundYield 103.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-fluoro-4-methylnicotinic acid (386 mg) and 1-(2,4-dicyclopropylphenyl)piperazine (650 mg), the title compound (980 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 27

Sources & evidence

ORD record
ord-90a86ade4c79487da57f49130a31fdda
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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