HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoro-5-methylpyridine-3-carboxylic acid → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-5-methylpyridin-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoro-5-methylpyridine-3-carboxylic acid | HCID 16414223 | — |
| Reactant | 1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine | HCID 58484718 | — |
| Product | [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](6-fluoro-5-methylpyridin-3-yl)methanone | HCID 58484721 | 52.6% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 60 and using 6-fluoro-5-methylnicotinic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.4 g) described in Preparation Example 96, the title compound (1.2 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-ffb25e03bcdc43ccae879c4e4b4a099a |
| Source note | uspto-grants-2013_01 |