5-Bromopyridine-2-carboxylic acid → HCID 58484818, compound

HRID 1804103Notes

Reaction equation

HRID 1804103 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484818HCID 58484818, compoundYield 47%

Procedure

By reaction and treatment in the same manner as in Preparation Example 60 and using 5-bromo-2-picolinic acid (1.5 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.8 g) described in Preparation Example 96, the title compound (1.4 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 60
  3. customdescribed in Preparation Example 96

Sources & evidence

ORD record
ord-b6bb28e39738487080806e55eb8519e0
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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