HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(4-bromo-2-fluorobenzoyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Product | Tert-butyl 4-(4-bromo-2-fluorobenzoyl)piperazine-1-carboxylate | HCID 51306443 | 94.9% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-fluorobenzoic acid (8.76 g) and piperazine-1-carboxylic acid tert-butyl ester (8.2 g), the title compound (14.7 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-b89c141e9485495ea505be404a40022b |
| Source note | uspto-grants-2013_01 |