(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)2-fluoro-benzoyl]piperazine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one	HCID 16213752	—
Reactant	HCID 51306443	HCID 51306443	—
Product	(R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)2-fluoro-benzoyl]piperazine-1-carboxylic acid tert-butyl ester	HCID 54755235	49.9%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 91 and using 4-(4-bromo-2-fluorobenzoyl)piperazine-1-carboxylic acid tert-butyl ester (3.49 g) described in Preparation Example 154 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (1.99 g), the title compound (2.37 g) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-c3888c2eaf074f35bf9f74dbd0b30ad4
Source note	uspto-grants-2013_01