Methyl iodide → HCID 54755237, compound

HRID 1804110Notes

Reaction equation

HRID 1804110 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:30])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][OH:27])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][C:16]=2[F:29])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:31]I>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:30])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][O:27][CH3:31])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][C:16]=2[F:29])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 54755236HCID 54755236, compound

Product 1

HCID 54755237HCID 54755237, compoundYield 69.1%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-4-[2-fluoro-4-(4-hydroxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester (1.64 g) described in Preparation Example 156 and methyl iodide (658 mg), the title compound (1.17 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-b6ac3ce2771b4978a8d2018d17c7f463
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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