Methyl iodide → HCID 58484662, compound

HRID 1804118Notes

Reaction equation

HRID 1804118 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:33])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][OH:27])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][C:16]=2[S:29]([CH3:32])(=[O:31])=[O:30])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:34]I>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:33])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][O:27][CH3:34])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][C:16]=2[S:29]([CH3:32])(=[O:31])=[O:30])[CH2:10][CH2:9]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484725HCID 58484725, compound

Product 1

HCID 58484662HCID 58484662, compoundYield 79%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-4-[4-(4-hydroxymethyl-2-oxooxazolidin-3-yl)-2-methanesulfonylbenzoyl]piperazine-1-carboxylic acid tert-butyl ester (908 mg) described in Preparation Example 170 and methyl iodide (320 mg), the title compound (738 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-6fa0eaabc719432e945cd2d2e6163595
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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