Sodium Hydroxide → 4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

To methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate (5.57 g) described in Preparation Example 116 were added ethanol (43 mL) and 1N aqueous sodium hydroxide solution (21.7 mL) and the mixture was stirred at 60° C. for 40 min. Ethanol was evaporated and the mixture was neutralized with water and 1N hydrochloric acid under ice-cooling and the mixture was stirred. The precipitated crystal were collected by filtration to give the title compound (5.25 g).

Provenance & Evidence