4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid → [4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804124Notes

Reaction equation

HRID 1804124 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][S:12]2(=[O:17])=[O:16])[CH:3]=1.[CH:18]1([C:21]2[CH:22]=[C:23]([CH3:33])[C:24]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:25][CH:26]=2)[CH2:20][CH2:19]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:30]2[CH2:31][CH2:32][N:27]([C:24]3[C:23]([CH3:33])=[CH:22][C:21]([CH:18]4[CH2:19][CH2:20]4)=[CH:26][N:25]=3)[CH2:28][CH2:29]2)=[O:8])=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][S:12]2(=[O:17])=[O:16])[CH:3]=1

Participants

3

Reactant 2

HCID 549330084-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484554[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 88.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid (6.72 g) described in Preparation Example 178 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (4.56 g) described in Preparation Example 96, the title compound (9.68 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 96

Sources & evidence

ORD record
ord-686f69828ba5477c8a413755b761961f
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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