4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid → [4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804125Notes

Reaction equation

HRID 1804125 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][S:12]2(=[O:17])=[O:16])[CH:3]=1.[CH2:18]([C:20]1[CH:21]=[C:22]([CH3:32])[C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:24][CH:25]=1)[CH3:19]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:29]2[CH2:30][CH2:31][N:26]([C:23]3[C:22]([CH3:32])=[CH:21][C:20]([CH2:18][CH3:19])=[CH:25][N:24]=3)[CH2:27][CH2:28]2)=[O:8])=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][S:12]2(=[O:17])=[O:16])[CH:3]=1

Participants

3

Reactant 2

HCID 549330084-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acidHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484567[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 94.1%

Procedure

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid (4.80 g) described in Preparation Example 178 and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (3.08 g) described in Preparation Example 53, the title compound (7.16 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 53

Sources & evidence

ORD record
ord-d06fdd58aadf4c0ba330592cc1450cf4
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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