4-Bromo-2,6-difluorobenzoic acid → (4-Bromo-2,6-difluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804129Notes

Reaction equation

HRID 1804129 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:5]([C:6]([OH:8])=O)=[C:4]([F:12])[CH:3]=1.[CH3:13][C:14]1[CH:15]=[CH:16][C:17]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:18][CH:19]=1>>[Br:1][C:2]1[CH:3]=[C:4]([F:12])[C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[CH:16]=[CH:15][C:14]([CH3:13])=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:8])=[C:9]([F:11])[CH:10]=1

Participants

3

Reactant 2

HCID 27732984-Bromo-2,6-difluorobenzoic acidHCID 114807791-(5-Methyl-2-pyridinyl)piperazine

Product 1

HCID 58484560(4-Bromo-2,6-difluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 66.3%

Procedure

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2,6-difluorobenzoic acid (1.56 g) and 1-(5-methylpyridin-2-yl)piperazine (1.06 g) described in Preparation Example 183, the title compound (1.57 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 183

Sources & evidence

ORD record
ord-4bc520408c5947fb98375d76453fb418
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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