HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzoic acid → (4-Bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Reactant | 1-(5-Cyclopropylpyridin-2-yl)piperazine | HCID 58484840 | — |
| Product | (4-Bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484657 | 85.3% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-fluorobenzoic acid (1.2 g) and 1-(5-cyclopropylpyridin-2-yl)piperazine (1.02 g) described in Preparation Example 187, the title compound (1.73 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-d323194e6b454d2b92ac0cc876454b07 |
| Source note | uspto-grants-2013_01 |