4-Bromo-2,6-difluorobenzoic acid → (4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804132Notes

Reaction equation

HRID 1804132 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:5]([C:6]([OH:8])=O)=[C:4]([F:12])[CH:3]=1.[CH:13]1([C:16]2[CH:17]=[CH:18][C:19]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[N:20][CH:21]=2)[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:3]=[C:4]([F:12])[C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:19]3[CH:18]=[CH:17][C:16]([CH:13]4[CH2:15][CH2:14]4)=[CH:21][N:20]=3)[CH2:23][CH2:24]2)=[O:8])=[C:9]([F:11])[CH:10]=1

Participants

3

Reactant 2

HCID 27732984-Bromo-2,6-difluorobenzoic acidHCID 584848401-(5-Cyclopropylpyridin-2-yl)piperazine

Product 1

HCID 58484548(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanoneYield 88.9%

Procedure

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2,6-difluorobenzoic acid (1.20 g) and 1-(5-cyclopropylpyridin-2-yl)piperazine (1.15 g) described in Preparation Example 187, the title compound (1.90 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 187

Sources & evidence

ORD record
ord-527e661c79384a75a53ea16f4a69c358
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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