2-Bromo-4-chlorobenzoic acid → HCID 58484687, compound

HRID 1804138Notes

Reaction equation

HRID 1804138 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:12]1([C:15]2[CH:16]=[C:17]([CH3:27])[C:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[N:19][CH:20]=2)[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:24]1[CH2:25][CH2:26][N:21]([C:18]2[C:17]([CH3:27])=[CH:16][C:15]([CH:12]3[CH2:13][CH2:14]3)=[CH:20][N:19]=2)[CH2:22][CH2:23]1)=[O:6]

Participants

3

Reactant 2

HCID 331262-Bromo-4-chlorobenzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484687HCID 58484687, compoundYield 103.4%

Procedure

By reaction and treatment in the same manner as in Preparation Example 60 and using 2-bromo-4-chlorobenzoic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (0.923 g) described in Preparation Example 96, the title compound (1.91 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 60
  3. customdescribed in Preparation Example 96

Sources & evidence

ORD record
ord-251342f304904f7c8a31e0ca69ae0809
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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