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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804152Generated: October 30, 2026

4,4-Dimethyl-1,3-oxazolidin-2-one → 3-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4,4-dimethyloxazolidin-2-one

https://huagongshe.com/reaction/1804152

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,4-Dimethyl-1,3-oxazolidin-2-oneHCID 141315—
Reactant(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 58484856—
Product3-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4,4-dimethyloxazolidin-2-oneHCID 6738074014.9%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (785 mg) described in Preparation Example 9 and 4,4-dimethyloxazolidin-2-one (200 mg), the title compound (126 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-8ed4f433f33a436f97b2e1a7d86f00d9
Source noteuspto-grants-2013_01