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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804155Generated: October 26, 2026

(4R)-4-tert-Butyl-1,3-oxazolidin-2-one → 4-Tert-butyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804155

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4R)-4-tert-Butyl-1,3-oxazolidin-2-oneHCID 2734860—
Reactant(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 58484856—
Product4-Tert-butyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-oneHCID 673814000.9%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (903 mg) described in Preparation Example 9 and (R)-4-tert-butyloxazolidin-2-one (286 mg), the title compound (9 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-1df7eed66a4a4adaba3f6c3216cb1f16
Source noteuspto-grants-2013_01