HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-4-tert-Butyl-1,3-oxazolidin-2-one → 4-Tert-butyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-4-tert-Butyl-1,3-oxazolidin-2-one | HCID 2734860 | — |
| Reactant | (4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone | HCID 58484856 | — |
| Product | 4-Tert-butyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-one | HCID 67381400 | 0.9% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (903 mg) described in Preparation Example 9 and (R)-4-tert-butyloxazolidin-2-one (286 mg), the title compound (9 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-1df7eed66a4a4adaba3f6c3216cb1f16 |
| Source note | uspto-grants-2013_01 |