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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804157Generated: October 31, 2026

(R)-(+)-4-Isopropyl-5,5-dimethyl-2-oxazolidinone → (R)-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4-isopropyl-5,5-dimethyloxazolidin-2-one

https://huagongshe.com/reaction/1804157

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-(+)-4-Isopropyl-5,5-dimethyl-2-oxazolidinoneHCID 10583042—
Reactant(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 58484856—
Product(R)-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4-isopropyl-5,5-dimethyloxazolidin-2-oneHCID 6738101842.8%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (722 mg) described in Preparation Example 9 and (R)-(+)-4-isopropyl-5,5-dimethyloxazolidin-2-one (250 mg), the title compound (359 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-a40b65cab9194b8d96f43164398b4cd1
Source noteuspto-grants-2013_01