2-Oxazolidinone → HCID 54754999, compound

HRID 1804161Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([Cl:24])[CH:3]=1.[O:25]1[CH2:29][CH2:28][NH:27][C:26]1=[O:30]>>[Cl:24][C:4]1[CH:3]=[C:2]([N:27]2[CH2:28][CH2:29][O:25][C:26]2=[O:30])[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=2[CH3:23])[CH2:12][CH2:11]1)=[O:9]

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 58484715HCID 58484715, compound

Product 1

HCID 54754999HCID 54754999, compoundYield 52.9%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (814 mg) described in Preparation Example 11 and oxazolidin-2-one (174 mg), the title compound (437 mg) was obtained.

Workup

customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-4aa73bd07f35418fbd5f82826656fdba
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354401B2

Reaction notes

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