Toluene → HCID 54754890, compound

Participants

Reaction Steps

To a mixture of 3-{3-chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one (347 mg) described in Example 21, bis(tricyclohexylphosphine)palladium (II) dichloride (33 mg), tripotassium phosphate (956 mg) and cyclopropylboronic acid (172 mg) were added toluene (4 mL) and water (200 μL), and the mixture was refluxed for 6 hr. After cooling, water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and the solvent was evaporated. The residue was purified by column chromatography (chloroform:methanol) to give the title compound (81 mg).

Provenance & Evidence