Hydrochloric Acid → HCID 67381033, compound

Participants

Reaction Conditions

Reaction Steps

To methyl (R)-4-(4-benzyl-2-oxooxazolidin-3-yl)benzoate (0.19 g) described in Preparation Example 22 were added 1N aqueous sodium hydroxide solution (0.92 mL), methanol (5 mL) and 1,4-dioxane (1 mL), and the mixture was stirred at 65° C. for 7 hr. 1N hydrochloric acid (0.92 mL) was added, 1-(2,4-dimethylphenyl)piperazine (0.116 g) and 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (0.17 g) were added, and the mixture was stirred at room temperature. After completion of the reaction, the mixture was extracted with ethyl acetate, washed with saturated brine, and the solvent was evaporated. The residue was purified by column chromatography (chloroform) to give the title compound (175.4 mg).

Provenance & Evidence