HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-4-phenyl-1,3-oxazolidin-2-one → (R)-3-{5-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]pyridin-2-yl}-4-phenyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-4-phenyl-1,3-oxazolidin-2-one | HCID 730425 | — |
| Reactant | HCID 58484755 | HCID 58484755 | — |
| Product | (R)-3-{5-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]pyridin-2-yl}-4-phenyloxazolidin-2-one | HCID 67381071 | 4% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (749 mg) described in Preparation Example 20 and (R)-(−)-4-phenyloxazolidin-2-one (222 mg), the title compound (25 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-65a9c28b67de424e875fc731dfeca1d0 |
| Source note | uspto-grants-2013_01 |