(4R)-4-phenyl-1,3-oxazolidin-2-one → HCID 67380825, compound

HRID 1804173Notes

Reaction equation

HRID 1804173 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[C:24]1([C@@H:30]2[CH2:34][O:33][C:32](=[O:35])[NH:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[N:6]=[CH:7][C:2]([N:31]3[C@H:30]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:34][O:33][C:32]3=[O:35])=[CH:3][CH:4]=2)=[O:9])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 730425(4R)-4-phenyl-1,3-oxazolidin-2-oneHCID 58484574HCID 58484574, compound

Product 1

HCID 67380825HCID 67380825, compoundYield 20.1%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (5-bromopyridin-2-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (749 mg) described in Preparation Example 21 and (R)-(−)-4-phenyloxazolidin-2-one (326 mg), the title compound (183 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-bb69ebc0f90b477dbd6e6e63895758d8
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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