2-Oxazolidinone → HCID 67380913, compound

HRID 1804183Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([Cl:22])=[CH:20][C:19]([Cl:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[O:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33]>>[Cl:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:30]4[CH2:31][CH2:32][O:28][C:29]4=[O:33])=[CH:3][C:4]=3[S:24]([CH3:27])(=[O:26])=[O:25])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([Cl:23])[CH:20]=1

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 58484757HCID 58484757, compound

Product 1

HCID 67380913HCID 67380913, compoundYield 84.7%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dichloropyridin-2-yl)piperazin-1-yl]methanone (0.5 g) described in Preparation Example 74 and oxazolidin-2-one (130 mg), the title compound (429 mg) was obtained.

Workup

customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-90520d6492c4486bb385ed015ff5c915
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354401B2

Reaction notes

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