(4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	(4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-one	HCID 641505	—
Reactant	[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone	HCID 58484535	—
Product	(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one	HCID 67381097	36.9%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (567 mg) described in Preparation Example 77 and (R)-4-isopropyloxazolidin-2-one (192 mg), the title compound (210 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-2100cc4f8e044460a8ce018933c30e56
Source note	uspto-grants-2013_01