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HRID 1804199作成日：2026年10月25日

(4R)-4-ethyl-1,3-oxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4-ethyloxazolidin-2-one

https://huagongshe.com/reaction/1804199

反応式

関与物質

役割名称HCID仕込み量
反応物(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 641503—
反応物(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484626—
生成物(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4-ethyloxazolidin-2-oneHCID 6738080019.3%

反応手順

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.6 g) described in Preparation Example 65 and (R)-4-ethyloxazolidin-2-one (553 mg) described in Preparation Example 26, the title compound (336 mg) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08354401B2
出典データセットuspto-grants-2013_01
ORD IDord-7696d9101ded4962a39dd6a0a92cf564
出典メモuspto-grants-2013_01