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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804201Generated: October 30, 2026

(R)-(+)-4-Isopropyl-5,5-dimethyl-2-oxazolidinone → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-isopropyl-5,5-dimethyloxazolidin-2-one

https://huagongshe.com/reaction/1804201

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-(+)-4-Isopropyl-5,5-dimethyl-2-oxazolidinoneHCID 10583042—
Reactant(4-Bromo-2-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484835—
Product(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-isopropyl-5,5-dimethyloxazolidin-2-oneHCID 461901773.4%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (867 mg) described in Preparation Example 67 and (R)-(+)-4-isopropyl-5,5-dimethyloxazolidin-2-one (409 mg), the title compound (35 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-700705bbb84a4346b462cd7ed0ffaefd
Source noteuspto-grants-2013_01