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HRID1804210

反应详情

EQUATION

反应方程式

HRID 1804210 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H]1COC(=O)N1c1ccc(C(=O)O)cc1
HCID58484719

未命名化合物

结构：Cl.FC(F)(F)c1cnc(N2CCNCC2)c(C2CC2)c1
HCID67380779

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(c3ncc(C(F)(F)F)cc3C3CC3)CC2)cc1.Cl
HCID67380940

未命名化合物

收率 111.9%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 87 and using (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (221 mg) described in Preparation Example 37 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine hydrochloride (615 mg) described in Preparation Example 76, the title compound (571 mg) was obtained.

WORKUP

后处理

  1. customBy reaction and treatment in the same manner as in Example 87
  2. customdescribed in Preparation Example 76