HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid | HCID 58484719 | — |
| Reactant | 1-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochloride | HCID 67381094 | — |
| Product | (R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one hydrochloride | HCID 67447499 | 152.5% |
Reaction Steps
By reaction and treatment in the same manner as in Example 87 and using (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (221 mg) described in Preparation Example 37 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (487 mg) described in Preparation Example 50, the title compound (736 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-89f6f00a346c45eeb76f643cb309eaac |
| Source note | uspto-grants-2013_01 |