HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(3,5-dimethylpyrazin-2-yl)piperazine-1-carbonyl]phenyl]-4-methyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid | HCID 58484719 | — |
| Reactant | (3,5-Dimethylpyrazin-2-yl)piperazine hydrochloride | HCID 67381341 | — |
| Product | (R)-3-{4-[4-(3,5-dimethylpyrazin-2-yl)piperazine-1-carbonyl]phenyl]-4-methyloxazolidin-2-one | HCID 67380726 | 64.2% |
Reaction Steps
By reaction and treatment in the same manner as in Example 49 and using (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (422 mg) described in Preparation Example 37 and 1-(3,5-dimethylpyrazin-2-yl)piperazine hydrochloride (457 mg) described in Preparation Example 59, the title compound (484 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-6fdce8319516459d898d2dcfd82245a5 |
| Source note | uspto-grants-2013_01 |