(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → HCID 67380839, Verbindung

HRID 1804218Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804218
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[O:28]=[C:29]1[NH:33][C@H:32]([CH2:34][O:35]C(=O)C2C=CC=CC=2)[CH2:31][O:30]1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:33]4[C@H:32]([CH2:34][OH:35])[CH2:31][O:30][C:29]4=[O:28])=[CH:3][C:4]=3[S:24]([CH3:27])(=[O:26])=[O:25])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Komponenten

3

Edukt 2

HCID 16213752(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 58484505(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 67380839HCID 67380839, VerbindungAusbeute 57,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 19 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.6 g) described in Preparation Example 61 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (903 mg), the title compound (1 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 19

Quellen und Nachweise

ORD-Eintrag
ord-2d3c845f7eb94e8fbeec9d3b67ed7d2d
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

Notizen zur Reaktion

Wird geladen…