(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid → HCID 67380741, compound

HRID 1804220Notes

Reaction equation

HRID 1804220 reaction equation
[CH3:1][C@@H:2]1[CH2:6][O:5][C:4](=[O:7])[N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[ClH:17].[CH3:18][C:19]1[CH:20]=[C:21]([C:31]([F:34])([F:33])[F:32])[C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:23][CH:24]=1>>[ClH:17].[CH3:1][C@@H:2]1[CH2:6][O:5][C:4](=[O:7])[N:3]1[C:8]1[CH:9]=[CH:10][C:11]([C:12]([N:28]2[CH2:29][CH2:30][N:25]([C:22]3[C:21]([C:31]([F:34])([F:32])[F:33])=[CH:20][C:19]([CH3:18])=[CH:24][N:23]=3)[CH2:26][CH2:27]2)=[O:14])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acidHCID 67380803HCID 67380803, compound

Product 1

HCID 67380741HCID 67380741, compoundYield 10.5%

Procedure

By reaction and treatment in the same manner as in Example 87 and using (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (422 mg) described in Preparation Example 37 and 1-(5-methyl-3-trifluoromethylpyridin-2-yl)piperazine hydrochloride (282 mg) described in Preparation Example 55, the title compound (51 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 87
  2. customdescribed in Preparation Example 55

Sources & evidence

ORD record
ord-a703242a3bdf48c6839baae573f723ed
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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