(R)-4-Methyloxazolidin-2-one → HCID 67380818, compound

HRID 1804221Notes

Reaction equation

HRID 1804221 reaction equation
[Cl:1][C:2]1[C:3](I)=[CH:4][C:5]([O:24][CH3:25])=[C:6]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])[CH:7]=1.[CH3:27][C@@H:28]1[CH2:32][O:31][C:30](=[O:33])[NH:29]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])[C:5]([O:24][CH3:25])=[CH:4][C:3]=1[N:29]1[C@H:28]([CH3:27])[CH2:32][O:31][C:30]1=[O:33]

Participants

3

Reactant 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484862HCID 58484862, compound

Product 1

HCID 67380818HCID 67380818, compoundYield 29.4%

Procedure

By reaction and treatment in the same manner as in Example 79 and using (5-chloro-4-iodo-2-methoxyphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.5 g) described in Preparation Example 71 and (R)-4-methyloxazolidin-2-one (400 mg) described in Preparation Example 25, the title compound (225 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 79
  2. customdescribed in Preparation Example 25

Sources & evidence

ORD record
ord-4315b6e1d0ff42f798b2d5e1028f7522
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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