HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxazolidinone → 3-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxazolidinone | HCID 73949 | — |
| Reactant | (4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484572 | — |
| Product | 3-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}oxazolidin-2-one | HCID 67381428 | 68.1% |
Reaction Steps
By reaction and treatment in the same manner as in Example 111 and using (4-bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (392 mg) described in Preparation Example 66 and oxazolidin-2-one (87 mg), the title compound (271.1 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-91bee4ecba1d4862937bfb6d211ce998 |
| Source note | uspto-grants-2013_01 |