2-Oxazolidinone → HCID 67381406, compound

HRID 1804231Notes

Reaction equation

HRID 1804231 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[CH3:24].[O:25]1[CH2:29][CH2:28][NH:27][C:26]1=[O:30]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:27]4[CH2:28][CH2:29][O:25][C:26]4=[O:30])=[C:3]([CH3:24])[CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484593HCID 58484593, compound

Product 1

HCID 67381406HCID 67381406, compoundYield 13.4%

Procedure

By reaction and treatment in the same manner as in Example 111 and using (4-bromo-3-methylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (388 mg) described in Preparation Example 68 and oxazolidin-2-one (87 mg), the title compound (52.7 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 111

Sources & evidence

ORD record
ord-67d031f0765f4a15b2187af1f8c243c6
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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